新数据分析证实对男性生育能力的影响

作者: Hibz Y.D.

链接：

根据发表文章在FASEB杂志上的一项新科学研究，也可能对女性精子导致有害作用。

一项用意在于提高女性子代的科学研究发现一种叫作CB2的素特异性与精子生成的过程有关。科学研究执法人员解释真是，这一发现表明，可能会冲击女性的子代。

由意大利罗马大学Paola Grimaldi指派的科学研究团队让测试激素摄入不同的药物，其中一组摄入CB2特异性的活化剂，另一组则摄入CB2特异性抑制剂，第三组作为对照组只摄入生理盐水。科学研究结果表明，摄入CB2活化剂的激素有更快的生精速率，而摄入CB2抑制剂的激素则显示了相反的敏感度并有较慢的精子导致率。这些结果表明，CB2的转录需要维持一定的平衡状态以保证准确的精子导致过程。

FASEB杂志的总编辑Thoru Pederson反驳，这项科学研究意味著为女性不育症的病人开辟新的科学研究正向。他还真是：“内源性素对精子正常导致会有正面敏感度，如果采用可以进一步促使这种敏感度的激动剂，意味著的发展出病人女性不育症的一些新疗法”。

Marijuana Can Affect Male Fertility, Suggests New Study

The study focusing mainly on finding ways to enhance male fertility has found that a ‘marijuana receptor’ called CB2 (a cannabinoid receptor) is linked with the regulation of sperm production (a process named spermatogenesis). This might sound like good news, but the researchers of the study explain that this finding indicates that marijuana might thus be disrupting male fertility.

Led by Paola Grimaldi from the University of Rome Tor Vergata, Italy, the team treated mice with different agents: one group, with an activator of the CB2 receptor; another with an inhibitor of the same receptor; a third group acting as the control one received only a saline solution.

The findings show that the CB2 activator group had a more rapid rate of spermatogenesis while the inhibitor group displayed the opposite effect as they had a slower rate of sperm production. These results suggest that CB2 activation is needed to be in a certain balance for spermatogenesis to occur properly and adequately.

This research might be opening up new doors for the treatment of male infertility, as pointed out by the Editor-in-Chief of The FASEB Journal, Thoru Pederson. According to the latter, “the normal beneficial effects of endogenous cannabinoids on spermatogenesis can be stimulated further by a chemical mimic, an agonist, is a potentially promising new idea for treating male infertility“.

（文章来自抚顺九州家圆公立医院官方网站）